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Read MoreVagusX - VagusX intervenes in this dysregulation by providing artificial stimulation that mimics natural vagal activation. The electrical pulses trigger nerve fibres, sending signals up to the brainstem's nucleus tractus solitarius—the primary vagal processing centre. From here, cascading effects propagate throughout the nervous system. Heart rate variability increases, indicating improved autonomic balance. Inflammatory markers decrease, as vagus nerve activation suppresses excessive immune responses. Neurotransmitter systems shift, reducing cortisol (stress hormone) whilst increasing GABA (calming neurotransmitter) and acetylcholine (restoration neurotransmitter). These changes aren't merely biochemical—they translate into tangible subjective experiences: reduced anxiety, mental clarity, physical relaxation, and readiness for restful sleep.
Read MoreVagusX - Understanding how VagusX produces its effects requires examining the nervous system's fundamental organisation. The autonomic nervous system operates through two complementary branches: the sympathetic system, which mobilises resources for action and alertness, and the parasympathetic system, which conserves resources and promotes recovery. These aren't opposites but rather balancing forces—like accelerator and brake pedals in a car. Health depends not on eliminating either system but on maintaining appropriate balance between them.
Read MoreVagusX Non-invasive vagus nerve stimulation represents a significant evolution from traditional medical VNS, which requires surgical implantation of electrodes around the vagus nerve. First approved for treatment-resistant depression in 2005 and subsequently for epilepsy, implanted VNS demonstrated that targeted nerve modulation could produce meaningful clinical effects. However, surgical requirements limited accessibility and created risks that many patients couldn't justify for non-life-threatening conditions. nVNS emerged from research asking whether similar effects could be achieved through external stimulation.
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